Asymmetric iodine catalysis-mediated enantioselective oxidative transformations

Hydrogen bonding and alcohol effects in asymmetric hypervalent iodine catalysis: enantioselective oxidative dearomatization of phenols.

Highly Enantioselective Cascade Transformations by Merging Heterogeneous Transition Metal Catalysis with Asymmetric Aminocatalysis

The concept of combining heterogeneous transition metal and amine catalysis for enantioselective cascade reactions has not yet been realized. This is of great advantage since it would allow for the recycling of expensive and non-environmentally friendly transition metals. We disclose that the use of a heterogeneous Pd-catalyst in combination with a simple chiral amine co-catalyst allows for hig...

Copper-mediated asymmetric transformations*

Copper-catalyzed reactions include the enantioselective conjugate addition and the SN2′ substitution. We describe the genesis of these reactions, the choice of the primary organometallic reagent, and our studies on finding new Michael acceptors and new ligands. We also report on the use of the zinc enolate generated upon conjugate addition. INTRODUCTION Organocopper chemistry has found widespre...

Enantioselective hydrovinylation via asymmetric counteranion-directed ruthenium catalysis.

The first Ru-catalyzed enantioselective hydrovinylation has been realized by using an asymmetric counteranion-directed catalysis strategy. Styrene derivatives react with ethylene in excellent yields and promising enantioselectivity using this approach.

Enantioselective Oxidative Rearrangements with Chiral Hypervalent Iodine Reagents

A stereoselective hypervalent iodine-promoted oxidative rearrangement of 1,1-disubstituted alkenes has been developed. This practically simple protocol provides access to enantioenriched α-arylated ketones without the use of transition metals from readily accessible alkenes.